CGK733 was a synthetic chemical substance which was reported in 2006 to have remarkable properties in reversing cell senescence (aging). However, the entire work behind the discovery of this compound has since been found to be falsified and the authors of the original reports have retracted all their claims.
CGK733 was claimed to be an inhibitor of ATM/ATR kinases, which are involved in DNA damage repair. CGK was claimed to extend the lifetime of cultured cells by approximately 20 divisions, or roughly 25%, specifically in mammalian cells.
The original report garnered scientific attention, but was retracted in 2008. The retraction states that the screen to identify CGK733 as an anti-senescence agent was not carried out; experiments exploring the cellular effects of CGK733 were misrepresented; the identification of ATM as the target of CGK733 was fabricated; a compound which was essential for ATM target validation had not been synthesized; and the chemical structure of CGK733 was misrepresented.
The principal investigator, Tae Kook Kim, and several associates were consequently suspended from their positions at the Korea Advanced Institute of Science & Technology.
- ^ Won J, Kim M, Kim N, et al. (July 2006). "Small molecule-based reversible reprogramming of cellular lifespan". Nat. Chem. Biol. 2 (7): 369–74. doi:10.1038/nchembio800. PMID 16767085.
- ^ a b Dennis Normile and Jennifer Couzin (2008). "South Korean Researcher Suspended Over Charges of Scientific Misconduct". Science. http://sciencenow.sciencemag.org/cgi/content/full/2008/305/1. Retrieved 2008-03-17.
- ^ Kenneth J. Moore (2008). "Data Duping". Chemical & Engineering News. http://pubs.acs.org/isubscribe/journals/cen/86/i12/html/8612notw3.html. Retrieved 2008-04-01.
- ^ Bhattacharya S, Ray RM, Johnson LR (December 2008). "Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells". Cell. Signal. 21 (4): 509–22. doi:10.1016/j.cellsig.2008.12.003. PMID 19136059.
- ^ Crescenzi E, Palumbo G, de Boer J, Brady HJ (March 2008). "Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy". Clin. Cancer Res. 14 (6): 1877–87. doi:10.1158/1078-0432.CCR-07-4298. PMID 18347191.
- ^ Sarah Everts (2006). "Aging Cells Get New Lease On Life - Small molecule is found to extend lifetime of mammalian cells". Chemical & Engineering News. http://pubs.acs.org/cen/news/84/i25/8425notw4.html. Retrieved 2007-03-09.
- ^ a b Won J, Kim M, Kim N, et al. (July 2008). "Retraction: small molecule-based reversible reprogramming of cellular lifespan". Nat. Chem. Biol. 4 (7): 431. doi:10.1038/nchembio0708-431. PMID 18560433.